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Tirzepatide reached up to 20.9% weight reduction in SURMOUNT-1 (Jastreboff et al., N Engl J Med, 2022)

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The lack of MCP in spermatozoa was also described, associated with abnormal morphology of the mitochondrial capsules, with gaps between consecutive mitochondria, mitochondrial swelling, mitochondrial loss, cytoplasmic droplets, loose contacts of the mitochondrial helix with the plasma membrane, separations of the flagellar fibers and their protrusion, partially condensed chromatin, and fusions of midpiece and tail (104, 105, 169)